Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.

ABSTRACT: Post-traumatic bone loss occurs after major injuries like traumatic brain injury (TBI), spinal cord injury (SCI), burns, and fractures, yet its systemic effects remain underexplored. This review summarizes clinical and preclinical evidence, highlighting key mechanisms and their impact on fracture risk.

Introduction

Traumatic injuries can lead to systemic bone loss. While spinal cord injury (SCI)-related bone loss is well studied, the effects of TBI, burns, and fractures on bone metabolism remain less clear. This review examines post-traumatic bone loss across different injuries to guide future research, preventive, and treatment strategies.

Methods

We conducted a systematic review according to PRISMA guidelines. PubMed, Web of Science, Scopus, and Science Direct were searched

SUBMITTER: Rahmani A 

PROVIDER: S-EPMC12847244 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature