SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression.

ABSTRACT:

Introduction

Ovarian cancer (OC), particularly epithelial ovarian cancer (EOC), represents one of the most lethal and aggressive gynecological malignancies. Despite advances in surgery, chemotherapy, and immunotherapy, patient survival remains poor. Identifying novel molecular targets is crucial for improving early diagnosis and developing more effective therapies.

Methods

We examined the expression and immunoregulatory function of SLC40A1 in EOC using both experiments on cells and mouse orthotopic tumor models. Through integrated in vitro and in vivo studies, we systematically assessed the role of SLC40A1 in promoting M1 macrophage polarization and its relationship with tumor suppression, demonstrating that SLC40A1 enhances the response to immunotherapy.

Re

SUBMITTER: Wang G 

PROVIDER: S-EPMC12847247 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature