Strontium-doped hydroxyapatite microspheres loaded with iloprost promote dentin-pulp complex regeneration.

ABSTRACT:

Background

Vital pulp therapy (VPT) aims to preserve pulp vitality and tooth function. However, materials like calcium hydroxide and mineral trioxide aggregate have limitations in bioactivity, underscoring the need for improved biomaterials. Strontium-doped hydroxyapatite (Sr-HA) and pro-angiogenic agents have emerged as promising strategies to enhance dentin-pulp complex regeneration.

Methods

Hollow hydroxyapatite microspheres with 5%, 10%, and 15% Sr substitution were synthesized, and the optimal concentration was identified through Sr²⁺ release profiling and CCK-8-based cytocompatibility screening. Iloprost was subsequently loaded onto the selected 5% Sr-HA to obtain Ilo@Sr-HA. Human dental pulp stem cells (hDPSCs) were isolated from healthy extracted premolars

SUBMITTER: Chen J 

PROVIDER: S-EPMC12847251 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature