Glutamate potentiates susceptibility of P. aeruginosa clinical isolates to gentamycin: a new adjuvant hope for an old antibiotic.

ABSTRACT: Aminoglycosides have long been considered essential agents in P. aeruginosa chemotherapy; however, resistance is on the rise. Glutamate is a crucial molecule for all living organisms, serving a fundamental function in various metabolic activities. A deeper comprehension of metabolic flux may facilitate effective therapeutic strategies for the eradication of antibiotic-resistant microorganisms. In this work, we aim to investigate a novel approach of amino acid-antibiotic adjuvant to potentiate activity of existing therapeutics through a low-toxicity adjuvant strategy offering lower risk of unwanted effects. We used 25 P. aeruginosa whole-genome sequenced clinical isolates selected from a genomically diverse set of isolates. The effect of glutamate-gentamycin combination on bac

SUBMITTER: Nageeb WM 

PROVIDER: S-EPMC12847261 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature