Actinidia chinensis Planch Root extracts trigger ferroptosis in colorectal cancer via the p53/SLC7A11/GPX4 axis.

ABSTRACT:

Purpose

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Actinidia chinensis Planch Root extracts (acRoots), a traditional Chinese medicine (TCM), possess recognized anticancer properties, but their efficacy and mechanism in Colorectal cancer are not fully understood. This study investigates the role of acRoots in suppressing Colorectal cancer progression, with a specific focus on its potential to induce ferroptosis, a form of iron-dependent cell death.

Methods

The anti-tumor effects of acRoots were evaluated in human Colorectal cancer cell lines (HCT-15, CW-2) using Cell Counting Kit-8 (CCK-8), colony formation, wound healing, and Transwell assays. Cell death was analyzed by Annexin V-FITC/PI flow cytometry. Mechanisms were probe

SUBMITTER: Ma C 

PROVIDER: S-EPMC12847262 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature