Isotemporal substitution from sedentary behavior or sleep to physical activity: associations with depression risk in older adults-a systematic review and meta-analysis.

ABSTRACT:

Background and aims

As global population aging intensifies, mental health issues in older adults are increasingly prominent, with depression being particularly prevalent and detrimental. The study investigated how substituting sedentary behavior (SB) and sleep (SLP) with physical activity (PA) affects depression risk in this population.

Methods

Meta-analysis was conducted by searching four databases: PubMed, Scopus, SPORTdiscus, and PsycINFO (via EBSCOhost platform) for relevant studies published until January 2025. Regression coefficients (β) with 95% confidence intervals (CIs) for depressive symptoms were estimated. Publication bias was assessed using funnel plots and Egger's tests, and heterogeneity was evaluated using Q tests and the I² statistic. All statisti

SUBMITTER: Wang J 

PROVIDER: S-EPMC12847279 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature