Network pharmacological analysis, Mendelian randomization analysis and animal experimental reveal the mechanism of Wenxin Granules in inhibiting heart failure after myocardial infarction: apoptosis and inflammation.

ABSTRACT:

Background

Apoptosis and inflammation are the key pathological mechanisms of heart failure after myocardial infarction (MI-HF). Wenxin Granules (WXG), an effective compound that has been used clinically for more than 20 years, could improve cardiac function, lipids and blood rheology in patients with MI and delay the occurrence of HF. However, the exact mechanism is still unclear.

Methods

MI-HF mice model were established by permanent ligation of the left anterior descending, and the protective effects of WXG on cardiac function and fibrosis were evaluated by Elisa, echocardiography, Masson staining and HE staining. The core components of WXG and its targets and mechanisms of action in MI-HF were clarified by UPLC-MS/MS, network pharmacology and bioinformatics. The associati

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12847285 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature