Periodontitis is associated with altered salivary anti-SARS-CoV-2 antibody patterns in vaccinated individuals.

ABSTRACT:

Background

Periodontitis is characterized by chronic inflammation and mucosal barrier disruption, which may influence salivary antibody dynamics after systemic vaccination. This study investigated the impact of periodontal disease severity on salivary anti-SARS-CoV-2 antibody responses in vaccinated, non-infected individuals.

Methods

Saliva samples were collected from 258 SARS-CoV-2-naïve individuals who had received three vaccine doses. Participants were stratified into three groups based on a standardized oral examination: periodontally healthy controls (n=109), stage I/II periodontitis (n=93), and stage III/IV periodontitis (n=56). Anti-spike IgG, IgA, and sIgA levels were quantified using a validated in-house ELISA.

Results

Salivary anti-spike IgG levels were sign

SUBMITTER: Alkharaan H 

PROVIDER: S-EPMC12847319 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature