Global burden and genetic insights of RA and JIA in ages 0-19 years: GBD 2021 and MR analysis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic autoimmune arthritis that predominantly affects adults, whereas juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of childhood-onset arthritides defined by age at onset, clinical phenotype, and immunological profile. Although RA and JIA are classified as distinct diseases, they share overlapping clinical and immunological features, and the nosological relationship between RA and some JIA subtypes remains debated. The global burden of RA and JIA in young people, and the similarities and differences in their underlying immunogenetic features, remain incompletely understood.

Methods

We utilized GBD 2021 data to describe trends in incidence, prevalence, and disability-adjusted life years for RA in individuals ag

SUBMITTER: An P 

PROVIDER: S-EPMC12847325 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature