Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review.

ABSTRACT:

Background

Imipenem is a broad-spectrum carbapenem antibiotic for severe infections with significant pharmacokinetic (PK) variability. This review systematically synthesized published population pharmacokinetic (popPK) studies to identify key covariates and guide individualized dosing for patients with various conditions.

Methods

A systematic PubMed and Web of Science search identified imipenem popPK models. Studies employing nonlinear mixed-effects modeling in patients with various conditions were included, and data were extracted independently by two reviewers via a standardized form. The study characteristics and PK parameter estimates were compared.

Results

This systematic review of 18 popPK studies revealed that imipenem PKs were predominantly characterized by tw

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12847419 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature