Prognostic biomarkers for overall survival in patients undergoing surgery for bone metastases: a pan-cancer study.

ABSTRACT: Prompt diagnosis and prognostic assessment of bone metastases (BMs) remain challenging with most studies and prognostic models focusing on a single primary tumor and neglect host-related biomarkers. Therefore, this pan-cancer study aimed to evaluate bone metabolism, inflammatory, and hematological biomarkers in patients undergoing surgery for BMs, identify risk factors for BM development, and create a prognostic nomogram. A prospective cohort of adult patients with histologically confirmed BMs from various cancers was enrolled between 2020 and 2023. Baseline data included demographics, tumor type, and preoperative biomarkers such as bone turnover markers (P1NP, BAP), calcium, LDH, IGFBP-3, HALP, RDW, and NLR. Outcomes were recurrence, metastasis, and overall survival (OS), analyzed with Ka

SUBMITTER: Belluzzi E 

PROVIDER: S-EPMC12847445 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature