Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma.

ABSTRACT:

Background

Glioma is a highly heterogeneous and aggressive malignancy of the central nervous system, and reliable molecular biomarkers are urgently needed to improve prognostic stratification and guide therapeutic decision-making. The MEX3 family of RNA-binding proteins has been implicated in tumorigenesis and post-transcriptional regulation; however, their comprehensive roles in glioma remain poorly understood.

Methods

Integrated bioinformatic analyses were performed using transcriptomic and clinical data from TCGA, CGGA, and GEO cohorts to evaluate the expression profiles, diagnostic and prognostic value, genetic alterations, molecular interactions, immune infiltration characteristics, and functional pathways associated with MEX3A, MEX3B, MEX3C, and MEX3D. Protein-protein

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12847448 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature