Immunological profile of the tumor immune microenvironment of upper tract urothelial carcinoma predicts recurrence patterns.

ABSTRACT:

Background

The association between the tumor immune microenvironment (TiME) in upper tract urothelial carcinoma (UTUC) and its prognosis remains unclear. We investigated the relationship between TiME and UTUC recurrence patterns.

Methods

We evaluated 90 patients who underwent nephroureterectomy for UTUC and divided them into nonrecurrence, distant metastasis, and intravesical recurrence-only groups. We assessed the association of the TiME with clinicopathological factors using surgical tissues and the prognosis of the three groups via multiplex fluorescence immunohistochemistry.

Results

The median age was 71 years (44-89), and 58 (64%) were male. Intratumoral CD4⁺ T cell density was significantly higher in the nonrecurrence group (p = 0.0004) than the other

SUBMITTER: Takahashi K 

PROVIDER: S-EPMC12847598 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature