Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections.

ABSTRACT:

Background

Critically ill patients in intensive care units (ICUs) experience high rates of hospital-acquired (nosocomial) infections, commonly caused by translocation and dissemination of pathogenic microorganisms that colonize the intestinal tract (pathobionts). Multiple immune barriers protect the host against commensal and pathogenic colonizers, including a repertoire of circulating anti-commensal antibodies. The integrity of this systemic antibody-mediated defense system, its relationship with gut microbiota dysbiosis, and its impact on nosocomial infections in the ICU have not been explored.

Results

We performed a longitudinal cohort study of 46 critically ill patients at day 1 and day 3 of their ICU admission compared to 28 healthy volunteer controls. Circulating IgM,

SUBMITTER: Cho NA 

PROVIDER: S-EPMC12847606 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature