[¹⁷⁷Lu]Lu-DOTA-TATE tumour and organ time-activity curves: prediction from a single-time-point [⁶⁸Ga]Ga-DOTA-TATE PET/CT measurement.

ABSTRACT:

Aim

Predicting the time-activity curve (TAC) of [¹⁷⁷Lu]Lu-DOTA-TATE for organs at risk and neuroendocrine tumours (NETs) is an essential element in the calculation of the absorbed dose (AD) and a critical step for individualising peptide receptor radionuclide therapy (PRRT) treatment planning. This study aims to predict the TAC of [¹⁷⁷Lu]Lu-DOTA-TATE using a single quantitative image of [⁶⁸Ga]Ga-DOTA-TATE and population data with a physiologically based pharmacokinetic (PBPK) model.

Methods

A PBPK model was developed for [⁶⁸Ga]Ga-DOTA-TATE and [¹⁷⁷Lu]Lu-DOTA-TATE, including organs and NETs. To generate reference TACs, general physiological parameters were taken from the literature, while individual model parameters were

SUBMITTER: Vasic V 

PROVIDER: S-EPMC12847613 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature