Expression of pluripotency stem cell markers in endometrial hyperplasia.

ABSTRACT:

Background

Endometrial hyperplasia, a precursor to endometrial cancer, is increasing due to rising obesity and lifestyle risks. Scarce data exist on the molecular characterization of endometrial hyperplasia for prognostic and preventive applications,Objectives:This study investigates the expression of core pluripotency stem cell markers in endometrial hyperplasia, given their emerging role in cancer stem cell regulation in various cancers, including endometrial cancer,Design:This is a case-control study utilizing archival endometrial tissue blocks. In this study, we assessed the immunohistochemical expression of NANOG, OCT4, and SOX2 in hyperplastic endometrium compared to benign non-hyperplastic endometrium obtained from women with abnormal uterine bleeding,Results:The investigati

SUBMITTER: Mousa NA 

PROVIDER: S-EPMC12847657 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature