Soft sonocapacitor with topologically integrated piezodielectric nanospheres enables wireless epidural closed-loop neuromodulation.

ABSTRACT: Capacitively coupled electrical stimulation modulates neuronal activity through reversible charging and without charge transfer reactions. This represents a promising and safe neuromodulation scheme but achieving wireless and high capacitive charge density injection remains challenging. Here, we developed a topological fibrous-architecture sonocapacitor (SonoCap) that assembled from piezoelectric-dielectric composite nanosphere (UCapT) and two-dimensional cellulose. UCapT features a unique piezoelectric core-hollow cavity-dielectric cage structure that can efficiently couples ultrasound excitation to achieve piezoelectric electron-capacitance transfer, and its highly assembled SonoCap achieves cumulative charge storage, a high ion-accessible surface area, and macroscopic softness, thereby

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12847738 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature