ABSTRACT: Bromodomain adjacent to zinc finger domain 2B (BAZ2B) is involved in chromatin remodeling, non-coding RNA regulation, and aging. However, its role in cancer remains unclear. Using multiple databases (TCGA, GEO, GTEx, TIMER2.0, cBioPortal), we found that BAZ2B is downregulated in many cancers, including breast cancer. Low BAZ2B correlates with poor prognosis, immune infiltration, and diagnostic potential, as shown by ROC and Kaplan-Meier analyses. Functionally, BAZ2B knockdown promoted breast cancer cell proliferation, colony formation, migration, and invasion, but suppressed apoptosis. Western blotting showed that BAZ2B depletion decreased Bax and p53, but increased Bcl-2. BAZ2B deficiency increased lactate production and upregulated glycolytic enzymes (LDHA, HK1, HK2, PKM2, PFK1). This su
