Pilose antler extract promotes angiogenesis and vascular maturation to accelerate wound healing.

ABSTRACT: Angiogenesis plays a crucial role in early wound healing by providing essential nutrients and oxygen to tissue cells, supporting the growth of epithelial cells and other tissue cells. The essence of angiogenesis lies in the proliferation and migration of endothelial cells. Pilose antler extract (PAE) accelerates early-stage wound healing. Proteomic analysis shows its role in vascular tension regulation, cell migration, and angiogenesis. This study aims to investigate the effects and pharmacological mechanisms of PAE on angiogenesis and vascular maturation during the early stages of wound healing. We used a full-thickness skin excision model in rats, utilizing endothelial cell analysis to examine PAE's regulatory mechanisms on angiogenesis. In situ hybridization combined with CD31 immunoflu

SUBMITTER: Li L 

PROVIDER: S-EPMC12847804 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature