MiR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis.

ABSTRACT: Several microRNAs play vital roles in placental development. miR-155 has been implicated in placental development and can directly interact with a variety of targets, including angiotensin type II receptor 1 (AT₁R) (Agtr1) mRNA. The AT₁R is pro-proliferative and promotes early placental development. We therefore tested the hypothesis that miR-155 downregulates Agtr1 mRNA expression and impairs placental development. Placentae and fetuses from wild-type C57Bl/6 mice (miR-155^+/+, control) and C57Bl/6 mice with a null mutation in miR-155 (miR155^-/-) were mated with males of the same genotype and analyzed on gestational day 18.5, when placental morphology and miR-155 and AGTR1 expression were assessed. Additionally, HTR8/SVneo cells were cultured wit

SUBMITTER: Arthurs AL 

PROVIDER: S-EPMC12847812 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature