Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson's and inflammatory bowel disease.

ABSTRACT: Parkinson's disease (PD) is the fastest-growing neurodegenerative disease in the world¹. Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80% of individuals living with PD^2-4. We investigated peripheral relationships that may underlie mechanisms along the gut-blood axis that contribute to PD progression. Single-cell multiomic spatial molecular imaging (SMI) of colonic tissue localized and identified inflammatory injury within epithelial cells that appear to be associated with iron mishandling in both inflammatory bowel disease (IBD) and PD biosamples. We found that both the single-cell SMI of RNA and protein revealed parallel cross-modal dysregulation in the gut epithelium, in both IBD and PD biosamples. These data are accompan

SUBMITTER: Bolen ML 

PROVIDER: S-EPMC12847817 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature