Disorder-specific alterations of transient oscillatory dynamics during sleep across cortical and subcortical networks.

ABSTRACT: Transient sleep oscillations reflect the dynamic coordination of cortical and subcortical circuits, modulated by slow oscillatory activity. However, the disorder-specific signatures of these events across neurological, pain, and sleep disorders remain poorly characterized. In this exploratory study, we analyzed transient oscillatory dynamics in 99 individuals, including healthy controls and patients with narcolepsy type 1, non-REM parasomnia, idiopathic REM sleep behavior disorder, and fibromyalgia syndrome. Using slow oscillatory referenced time-frequency peak histograms, we applied principal and independent component analysis to uncover spectral and phase-coupling patterns across non-REM and REM stages. We identified reproducible, trait-like oscillatory structures in controls and disorde

SUBMITTER: Biabani N 

PROVIDER: S-EPMC12847891 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature