Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.

ABSTRACT: The hippocampus is classically linked to memory, yet increasing evidence points to a broader role in perceptual inference and deviance detection. Predictive coding theories propose that perception minimizes mismatches between expected and actual sensory input, expressed in neural signatures such as mismatch negativity (MMN) and P300. Although MMN arises mainly from sensory and prefrontal cortices, the hippocampus is anatomically interconnected with both and may also contribute to prediction error processing. We recorded single- and multi-unit activity and local field potentials (LFPs) from DG and CA1 in urethane-anesthetized rats during an auditory oddball paradigm and a no-repetition control sequence to dissociate prediction error from repetition suppression. Approximately 20% of hippocam

SUBMITTER: Sanchez JS 

PROVIDER: S-EPMC12847945 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature