Magnetoencephalography-based prediction of longitudinal symptom progression in Parkinson's disease.

ABSTRACT: Motor dysfunction in Parkinson's disease (PD) has been linked to widespread oscillatory changes within the basal ganglia-thalamic-cortical network, particularly in the beta frequency range. However, the evolution of cortical neurophysiological alterations and their relationship to clinical progression remain poorly understood. We conducted a longitudinal resting-state magnetoencephalography (MEG) study in 27 persons with PD and 30 healthy individuals with a mean follow-up time of 4 years. Source-reconstructed MEG data were parcellated into cortical regions, from which power spectra were parameterized to separate oscillatory peaks from the aperiodic component. An increase in the aperiodic exponent in the left postcentral region was associated with progression of rigidity. Peak beta power in

SUBMITTER: Waldthaler J 

PROVIDER: S-EPMC12847951 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature