The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins.

ABSTRACT: The common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca²⁺-dependent mechanisms, such as microvesicle shedding and annexin recruitment to resist cholesterol-dependent cytolysins like streptolysin O (SLO), or annexin involvement and patch repair in the case of aerolysin. However, the specific Ca²⁺-dependent repair pathways engaged in response to candidalysin remain poorly understood. Here, we determined the involvement of different Ca²⁺-dependent repair mechanisms to candidalysin and compared responses to SLO and aerolysin using flow cytometry and high-resolution microscopy. We report that candidalysin triggered Ca²⁺-dependent repair, but patch repa

SUBMITTER: Thapa R 

PROVIDER: S-EPMC12847973 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature