Adaptive evolution of Pseudomonas aeruginosa ST299 population colonizing a hospital copper water network over a 2.5-year period.

ABSTRACT: Background. Descriptions of genomic characters and dynamics related to Pseudomonas aeruginosa (PA) adaptation and survival in hospital water networks remain scarce but necessary for sustainable water management in hospitals.Methods. A new copper water network in an intensive care unit (ICU) was chronically colonized by a genotype sequence type (ST) 299 of PA and sporadically by a genotype ST2685. Sixty-eight ST299-PA and four ST2685-PA strains from ICU-water samples collected over 29 months and 4 months, respectively, were studied for genomic adaptation to copper water network. PFGE and whole-genome sequencing allowing SNP, comparative genomics, resistome, virulome and pangenome analyses were performed. In order to understand the adaptive phenomena linked to the coloni

SUBMITTER: Virieux-Petit M 

PROVIDER: S-EPMC12847981 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature