Hippocampal synchrony dynamically gates cortical connectivity across brain states.

ABSTRACT: Memory consolidation is thought to rely on hippocampo-cortical dialogue orchestrated by three cardinal sleep oscillations: cortical slow oscillations, thalamic spindles, and hippocampal sharp-wave ripples. However, how hippocampal outputs are routed to specific cortical targets and dynamically regulated across brain states remains unclear. Here, we performed simultaneous multisite recordings from the dorsal and ventral hippocampus, and frontal and retrosplenial cortex in rats alternating between wakefulness and sleep. Frontal slow oscillations operated as a global temporal scaffold, resetting thalamic circuits and initiating spindle volleys in both anterior and posterior cortex, while retrosplenial slow oscillations more effectively recruited hippocampal ripples. Ripple-spindle reflected d

SUBMITTER: Lazcano G 

PROVIDER: S-EPMC12848048 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature