Differential effects of HDAC inhibitors in the Rho^I255d mouse model for autosomal dominant retinitis pigmentosa.

ABSTRACT: Retinitis Pigmentosa (RP) is an inherited neurodegenerative disease which leads to loss of retinal photoreceptors and blindness. Histone deacetylases (HDAC) were previously found to be involved in photoreceptor cell death, and HDAC inhibitors have shown protective effects in animal models for autosomal recessive RP. However, whether HDAC inhibitors can protect photoreceptors in autosomal dominant RP (ADRP) remains unclear. Here, we utilized the recently generated human homologous Rho^I255d/+ ADRP mouse model to investigate degenerative mechanisms and the therapeutic potential of HDAC inhibitors. To visualize photoreceptor HDAC activity, we applied an in situ HDAC activity assay on post-natal (P) day 20 wild type (WT) and Rho^I255d/+ retina. Treatment with the HDAC class

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12848085 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature