Disruptive effects of phthalates and their substitutes on adrenal steroidogenesis.

ABSTRACT:

Introduction

Phthalates are ubiquitous plasticizers known for their endocrine-disrupting properties, notably affecting reproductive and cardiovascular health. Emerging substitutes such as DEHT and DINCH are increasingly use, but may turn out to be "regrettable substitutes" with similar toxicological concerns. Though the effects of phthalates and substitutes on adrenal steroidogenesis and related endocrine systems (e.g., renin-angiotensin-aldosterone system, hypothalamic-pituitary axis) remain poorly understood.

Methods

In this study, steroidogenic NCI-H295R adrenocortical cells were exposed for 72 hours to phthalates (DEHP, DiBP, DiNP), substitutes (DEHA, DEHT, DINCH), and a cumulative mixture at concentrations ranging from 1 nM to 1 mM. DMSO vehicle controls were included i

SUBMITTER: Potzl B 

PROVIDER: S-EPMC12848149 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature