Elucidating the anti-fibrotic mechanisms of Abrus cantoniensis in hepatic fibrosis using network pharmacology and proteomics.

ABSTRACT: This study aimed to elucidate the effects and underlying mechanisms of Abrus cantoniensis in treating mice hepatic fibrosis, thereby providing a rationale for its clinical application. To investigate A. cantoniensis effects in hepatic fibrosis, we established a carbon tetrachloride-induced mouse model validated by histopathology. Potential active compounds were revealed through LC-MS, and core targets were identified by network pharmacology integrated with proteomics. Validation was performed using molecular docking, molecular dynamics, and immunohistochemistry. Histopathology confirmed the anti-hepatic fibrosis effects of A. cantoniensis. The LC-MS analysis identified 420 compounds, while network pharmacology and proteomics revealed 208 and 738 key targets, respectively. Functional enrich

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC12848311 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature