Computational Fluid Dynamic Analysis of Fluid Motion and Volumetric Gas-Liquid Mass Transfer in Agitated Platelet Concentrate Storage.

ABSTRACT: Computational fluid dynamics (CFD) offers a powerful tool in characterizing the complex biophysical environment inducing by dynamic storage conditions, providing insights often beyond the reach of conventional experimental approaches. As our understanding of platelet (PLT) biology has advanced, increased attention has been directed toward mechanical stresses, attributing shear forces encountered during collection, processing, and storage to an acceleration decline in PLT concentrate (PC) quality. CFD simulations using the volume of fluid model were used to simulate PC storage under varying agitation frequencies. Key parameters assessed include fluid velocity, wall shear stress (WSS), and gas-liquid mass transfer. Agitation increased fluid velocity and WSS while preserving the temporal symm

SUBMITTER: Pym D 

PROVIDER: S-EPMC12848328 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature