Probing the Influence of Paternal Diet on Offspring Neuroanatomy With Mouse MRI.

ABSTRACT:

Purpose

Previous studies have established that parental consumption of a diet high in fat and simple sugar (HF/HSS) leads to long-term effects on offspring brain development. However, most studies have focused on the effects of maternal diets or the combined effects of both parents' diets. As literature suggests that fathers' environmental factors can also impact offspring brain development, we aimed to explore the impact of isolated paternal consumption of an HF/HSS diet on offspring brain structure.

Methods

C57Bl/6J male mice were acclimated to an HF/HSS diet for eight weeks prior to mating with females who consumed standard chow (control diet, CD). A matching paternal control group was fed the CD during the acclimation period. Throughout gestation and lactation all dams a

SUBMITTER: McKnight EGW 

PROVIDER: S-EPMC12848517 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature