Age-Related Genetic Causal Association Between Asthma and Delirium: A Bidirectional Two-Sample Mendelian Randomization.

ABSTRACT:

Introduction

Despite observational studies suggesting a link between asthma and delirium, establishing a definitive causal relationship has been challenging. This study aims to investigate the genetic causality between these conditions, with a particular focus on age-related genetic associations using data from large-scale genome-wide association studies (GWASs).

Methods

Bidirectional two-sample Mendelian Randomization (MR) analyses were performed using GWAS summary statistics to evaluate the genetic association between asthma (overall, adult-onset, childhood-onset, and age at asthma diagnosis) and delirium. The inverse variance-weighted (IVW) method was the primary analytic approach, supplemented by weighted median, weighted mode, and MR-Egger methods. Multivariable Mendeli

SUBMITTER: Wang X 

PROVIDER: S-EPMC12848525 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature