Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort.

ABSTRACT:

Importance

Sex differences in Alzheimer disease (AD) neuropathology have not been examined extensively across multiple pathological constructs within broadly representative samples.

Objective

To examine sex differences in neuroimaging biomarkers of AD-related pathologies in a racially and ethnically diverse cohort.

Design, setting, and participants

Data for this cross-sectional study were collected from a community-based sample of adults without cognitive impairment aged 60 to 69 years in New York City from March 1, 2016, to September 31, 2022, and analyzed in March 2025.

Exposure

The primary exposure was self-reported sex (women or men).

Main outcomes and measures

The outcomes were global amyloid burden measured with florbetaben labeled with fludeoxyglu

SUBMITTER: Akinci M 

PROVIDER: S-EPMC12848629 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature