Organic Heterojunction Nanoparticles: Photoinduced Charge Transfer and Melanin-Amplified ROS Generation for Melanoma Photodynamic Therapy.

ABSTRACT: Melanoma is a life-threatening cancer, requiring more effective treatments. Photodynamic therapy (PDT) is a promising approach with favorable biosafety, although its clinical efficacy remains limited. In this work, we developed a nanoplatform combining poly-(9,9-dioctylfluorene-alt-benzothiadiazole) (PFBT) and 1-[3-(methoxycarbonyl)-propyl]-1-phenyl-[6.6]-C₆₁ (PCBM), forming PFBT/PCBM (PP) nanoparticles, which contain a type II heterojunction that enables efficient charge transfer (≥97.7%) under irradiation. The resulting PFBT^+• and PCBM^-• radicals enable the generation of diverse reactive oxygen species (ROS) at high levels, including superoxide, hydroxyl radicals, and singlet oxygen (both type I and II ROS), through efficient electron and hole tran

SUBMITTER: Jin Q 

PROVIDER: S-EPMC12848670 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature