PIK3R1 as a Gastric Cancer Biomarker Linked to CD73 ⁺ Treg-Mediated Immunosuppression.

ABSTRACT:

Objectives

Gastric cancer (GC) remains a major global health concern, and Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), a regulatory subunit of the PI3K signaling pathway, may play a critical yet underexplored role in GC progression. This study aimed to investigate the prognostic significance of PIK3R1 in GC and its association with the tumor immune microenvironment.

Methods

PIK3R1 expression and its clinical relevance were analyzed using datasets from GC patients who underwent gastrectomy, including cohorts from The Cancer Genome Atlas (TCGA) and the Sun Yat-sen University Cancer Center (SYSUCC). Prognostic models integrating PIK3R1 expression with clinical parameters were constructed for both cohorts. The immune microenvironment associated with PIK3R1 expression

SUBMITTER: Zou B 

PROVIDER: S-EPMC12848688 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature