Temperature-Responsive Supramolecular Chiral Switch Achieved by Macrocyclic Confinement.

ABSTRACT: A series of tunable morphological nanoaggregates are constructed by hydroxypropyl-β/γ-cyclodextrin (HPβ/γCD) and cucurbit[8]-uril (CB[8]), respectively, encapsulating phenylalanine dipeptide-modified pyrene (PFF) based on host-guest complexation, which not only exhibits a topological transformation from helical nanofibers of PFF to supramolecular nanoparticles, nanotubes, and nanosheets but also induces chiral transmission from phenylalanine dipeptide to pyrene moiety achieving temperature-controlled supramolecular chiral switches. Unlike the encapsulation of HPβCD to PFF at a 1:1 stoichiometric ratio, HPγCD with larger cavity can encapsulate two PFFs, achieving enhanced fluorescence behavior with quantum yield increasing from 1.66% to 32.14% and circular dichroism (CD) with a negative Cot

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12848697 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature