Preclinical Evaluation Study of ⁶⁸Ga-Labeled PSMA-Targeted Dimer Probe.

ABSTRACT: The development of tracers targeting prostate-specific membrane antigen (PSMA) has great significance for improving the diagnosis and treatment of prostate cancer (PCa). In this study, a dimeric PSMA-targeting ligand, PSMA-DIM, has been designed and synthesized based on the structure of the Glu-urea-Lys pharmacophore by introducing 4-(p-iodophenyl) butyric acid and PEG₄ motifs. [ ⁶⁸ Ga]-Ga-PSMA-DIM exhibited high radiochemical purity (>98%) and stability, with a K _d value for LNCaP cells of 37.09 ± 13.53 nM. The uptake and internalization of [ ⁶⁸ Ga]-Ga-PSMA-DIM by LNCaP cells were significantly higher compared to 22Rv1 or PC-3 cells. The elimination half-life of [ ^68</

SUBMITTER: Xie Q 

PROVIDER: S-EPMC12848698 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature