Influences of Ring Sizes and Chiral Substituents on Macrocyclic Chelators for Improving ⁶⁸Ga Radiolabeling.

ABSTRACT: ⁶⁸Ga-labeled macrocyclic ligands have been extensively studied and used for positron emission tomography (PET) imaging. Compared with 12-membered DOTA derivatives, NOTA-based chelators with 9-membered macrocyclic rings exhibit more advantageous coordination stability for Ga³⁺ ions. However, studies of the 10-membered DETA macrocycle are still quite limited. Here, we present the synthesis of four different-sized chiral macrocyclic ligands L1-L4, followed by radiolabeling and stability studies to reveal the influence of ring size and chiral substituents on Ga³⁺ chelation. In the ⁶⁸Ga radiolabeling experiments, chiral NOTA L1 exhibits the highest radiochemical yield of 99% at 25 °C. While for the chiral DETA L2/L3 and the

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12848718 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature