The Frontier of Melanoma Treatment: Defeating Immunotherapy Resistance-A Systematic Review.

ABSTRACT:

Objectives

Immunotherapy based on immune checkpoint blockade (ICB) has become a key treatment for melanoma. However, the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop methods to overcome this resistance. This study aims to collect the most recent information on melanoma immunotherapy, discuss potential strategies to overcome resistance to immunotherapy, and identify areas that require further analysis.

Methods

To achieve this goal, scientific publications from 2021-2024 available in PubMed and Google Scholar databases were analyzed. The databases were searched using the following terms: "melanoma", "immunotherapy", "Immune Checkpoint Blockade", and "immunoresistance".

Results

The results of preclinical and early-stage

SUBMITTER: Mozga K 

PROVIDER: S-EPMC12848726 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature