Post Hoc Analysis of a Previous Study of Estetrol 15 mg/Drospirenone 3 mg Combination for Dysmenorrhea and Uterine Bleeding in Adenomyosis Patients.

ABSTRACT:

Purpose

To clarify the efficacy and safety of the estetrol 15 mg/drospirenone 3 mg combination among Japanese women with adenomyosis by post hoc analyses of a previous randomized clinical study.

Methods

Post hoc analyses were performed using data from a 16-week, multi-center, randomized, double-blinded, placebo-controlled, parallel-group study, followed by a 36-week, open-label extension study involving 162 Japanese women with dysmenorrhea. Participants received cyclic estetrol/drospirenone or placebo. The primary endpoint was the absolute change in total dysmenorrhea score from baseline to the end of the 16-week double-blinded period.

Results

Among participants with adenomyosis, estetrol/drospirenone reduced the change from baseline of the total dysmenorrhea score at

SUBMITTER: Harada T 

PROVIDER: S-EPMC12848778 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature