Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High CST2 Expression and a Favorable Prognosis.

ABSTRACT: Ovarian cancers with similar histopathologic but diverse immunogenomic profiles may require different treatment regimens to achieve the best clinical outcomes. The development of optimal treatment regimens will thus require an understanding of the main ways in which ovarian cancers differ with respect to their immunogenomic profiles. We used a multimodal latent variable model to enable an integrated analysis of somatic mutation, mRNA expression, and multiplex immunofluorescence data to uncover the principal drivers of intertumor heterogeneity across 197 patients with ovarian cancer. We found that the majority of the immunogenomic intertumor heterogeneity was driven by gene expression and immune infiltration in the tumor core and invasive margin. Moreover, much of this heterogeneity could n

SUBMITTER: Boyle J 

PROVIDER: S-EPMC12848861 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature