A Streamlined Protocol for Developing a Clinicopathological Prediction Model for Patient Survival of Post-Resection of Pancreatic Cancer.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDA) is one of the most malignant solid cancers. As surgery is the only cure, prediction of long-term survival post-resection is critical to guide patient selection for the subsequent treatment. Tumour immune evasion plays a key role in PDA tumorigenesis.

Materials and methods

Using a streamlined protocol, we developed a clinicopathological prediction model for the overall survival of patients with PDA after resection by integrating tumour immunological features and clinical data. Multiplex immunohistochemistry was performed using human tumour microarray samples. The results were combined with retrospectively collected clinical data of 79 patients. Variables were selected by least absolute shrinkage and selection operator (LASSO)

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12848901 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature