Multi-omic expression of the VEGF family relates to Alzheimer's disease across diverse populations.

ABSTRACT:

Introduction

The vascular endothelial growth factor (VEGF) signaling family plays a role in neurodegenerative diseases, including Alzheimer's disease (AD). Previous work has shown widespread effects of the members FLT1, FLT4, and VEGFB on AD outcomes. However, these analyses have focused within the non-Hispanic White (NHW) population.

Nethods

The goal of this study was to analyze the effects of the VEGF family in underrepresented populations, leveraging large and diverse bulk RNA sequencing and tandem mass tag-mass spectrometry (TMT-MS) proteomic data. Outcomes included measures of AD pathology and diagnosis.

Results

Within underrepresented populations, we replicated previously reported effects of FLT1 and FLT4, whereby higher protein abundance was observed in the AD

SUBMITTER: Libby JB 

PROVIDER: S-EPMC12848908 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature