PHoenix score discriminative ability in suspected gastroesophageal reflux disease: a high-volume single-center external validation.

ABSTRACT: The pHoenix score was recently developed to reduce the proportion of inconclusive diagnoses associated with using total acid exposure time (AET) alone. The aim of this study was to compare the discriminative performance of the pHoenix score to total AET and DeMeester score (DMS) in patients undergoing 24-hour transnasal pH-monitoring (24-h pH). This cross-sectional study included consecutive patients (2017-2024) undergoing 24-h pH for suspected gastroesophageal reflux disease. Exclusions criteria were prior foregut/bariatric procedures, outflow obstruction disorders and inadequate pH-studies (<18 hours). The pHoenix score calculation was (%upright AET × 0.991) + (% supine AET × 1.286), with thresholds: <7.06 (normal), 7.06-8.45 (borderline), >8.45 (pathological). Total AET thresholds were:

SUBMITTER: Vittori A 

PROVIDER: S-EPMC12848936 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature