Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.

ABSTRACT: Transcranial Focused Ultrasound Stimulation (tFUS) is a promising non-invasive technique capable of modulating brain activity with high spatial precision. However, its efficacy for seizure suppression requires further exploration. This study aims to address whether tFUS of white matter can suppress seizures non-invasively. Repeated injections of a 4-Aminopyridine (4-AP) cocktail into the right somatosensory cortex (S1) induced cortical seizures in male rats under anesthesia with recording of both EEG and intracranial signals. Approximately one hour of tFUS was applied to the corpus callosum (CC) using a 128-element random-array transducer with 20 ms pulse duration, 1 Hz pulse repetition frequency, 2% duty cycle, and ~127 kPa pressure. Another 2-3 hours were used to assess post-stimulation

SUBMITTER: Gao H 

PROVIDER: S-EPMC12848950 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature