Impact of peripheral artery disease (PAD) on risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes.

ABSTRACT:

Background

As of 2021, global estimates show that 536.6 million adults aged 20 to 79 years are living with type 2 diabetes (T2D), and the prevalence of T2D is projected to increase to about 783 million individuals by 2045. Peripheral artery disease (PAD), which is caused by atherosclerosis of the extremities (most commonly lower limbs) leading to the narrowing of blood vessels, is a major risk factor for lower extremity amputation and is a common comorbidity of diabetes. Patients with both T2D and PAD often have advanced systemic vascular disease, which may involve other vascular territories, such as the coronary and cerebral arteries. However, PAD is underdiagnosed and underrecognized, particularly at earlier stages of the disease.

Methods

This retrospective cohort study us

SUBMITTER: Amamoo J 

PROVIDER: S-EPMC12849000 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature