History of gestational diabetes, modifiable lifestyle factors, and risk of cardiovascular disease and mortality: a prospective cohort study.

ABSTRACT:

Background

Women with a history of gestational diabetes (GDM) have an increased risk of cardiovascular disease (CVD) throughout their lifetime. It is still unclear whether adhering to a healthy lifestyle can modify the association of GDM with the risk of CVD and mortality.

Methods

This study included 125,435 parous women from the UK Biobank prospective cohort. The history of GDM was determined by self-reported diagnosis or hospital admission records. A healthy lifestyle score was defined by incorporating self-reported information on five modifiable risk factors, including smoking, alcohol intake, physical activity, diet, and sleep duration. The primary outcome was a composite of major CVD and all-cause mortality.

Results

The mean age was 56.4 ± 7.9 yrs, and 668 partic

SUBMITTER: Li S 

PROVIDER: S-EPMC12849031 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature