MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E₂.

ABSTRACT:

Background

The resolution of inflammation is an active process triggered in the acute phase of inflammation and mainly directed by specialized pro-resolving mediators (SPMs). Modulating the inflammatory response in favor of resolution is a therapeutic strategy of enormous interest and value. Previous studies have shown that human adipose mesenchymal stem cells (MSCs) possess the ability to shorten the acute inflammatory response by hinting an early cyclooxygenase (COX)-2 induction. We studied the potential of MSC to accelerate the resolution of inflammation through the direct promotion of the local synthesis of SPMs, and the role of prostaglandin (PG) E₂ release in this process in a model of experimental acute arthritis.

Methods

Gouty arthritis was induced in male

SUBMITTER: Bermejo-Alvarez I 

PROVIDER: S-EPMC12849076 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature