A novel potent autophagy inhibitor HM-013 limits production of infectious dengue virus particles.

ABSTRACT:

Background

Dengue virus (DENV) infects millions of individuals annually, yet no specific antiviral therapy exists. Autophagy, a conserved cellular degradation pathway, is activated during DENV infection and supports the production of infectious virions. Although autophagy modulation has emerged as a potential antiviral strategy, few small-molecule autophagy inhibitors with both potent anti-dengue activity and low cytotoxicity have been reported. Thus, identifying novel, safe, and effective autophagy-targeting compounds remains an important unmet need for host-directed antiviral development.

Methods

We performed a high-content imaging screen of a natural product-derived compound library to identify autophagy inhibitors. Candidate compounds were evaluated for autophagy inhibit

SUBMITTER: Limthongkul J 

PROVIDER: S-EPMC12849096 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature